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KMID : 0604520060320030135
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 3 p.135 ~ p.140
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Herbal Extracts as a NF-kappaB Inhibitor
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Park Deok-Hoon
Lee Jong-Sung
Jung Eun-Sun
Hyun Chang-Gu
Lee Ji-Young
Hur Sung-Ran
Koh Jae-Sook
Lee Hee-Kyung
Baek Ji-Hwoon
Yoo Byung-Sam
Moon Ji-Young
Kim Joo-Ho
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Abstract
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Nuclear factor-kappaB (NF-kappaB) is a critical transcription factor for maximal expression of many of the cytokines that are involved in the pathogenesis of inflammatory diseases. In this study, we found that 12 plant extracts among 200 plants, namely, Forsythia koreana, Capsicum annuum L, Mentha arvenis, Duchesnea chrysantha, Morus alba, Saururus Chinenis (Lour) Baill, Pine needle, Zingiber mioga (Thunb.), Roscoe, Houttuynia, Prunus yedoenis, Sasa quelpaertenis, significantly inhibited LPS- induced NF-kappaB activation in a concentration-dependent manner. Additionally, 12 plant extracts were found to have antioxidant activities in DPPH assay Therefore, we have attempted to determine whether 12 herbal extracts could inhibit the expression of cytokines possessing NF-kappaB promoter in their promoter regions. Consistently 12 herbal extracts inhibited LPS-induced production of TNF alpha and interleukin-8 (IL-8). These results show that 12 herbal extracts suppresses the production of pro-inflammatory mediators through the inhibition of the NF-kappaB signaling pathway, we suggest that 12 herbal extracts can be used as a anti-inflammatory and soothing agent.
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KEYWORD
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NF-kappaB, interleukin-8, TNF alph, DPPH, cosmetics
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